△ 2026 · AI & Neuroscience
Technology to measure and non-invasively guide the brain into states of mindfulness. Engineering the end of suffering.
Read our Research →
60 hours of gold-standard mindfulness
meditation practice. Delivered in
an 80-second session.
Every purchase. Every relationship. Every habit. Every ambition.
Underneath the behaviour, there is always a brain state being sought.
Four chapters from first principles — written by our co-founder Raphael Biancale.
At fifteen, I was trapped in constant anxiety. In rare moments, it would disappear — replaced by something I had no words for: quiet, warmth, presence. That contrast became a thirty-year inquiry into what mental disorders actually are.
"What if the approaches aren't failing because of poor execution? What if the entire framework they are built on is wrong?"
Psychiatry borrowed the cellular pathology model from physical medicine — without ever finding cellular evidence. While oncology confirms cancer by identifying malignant cells under a microscope, psychiatry diagnoses by symptom self-report alone. No blood test. No brain scan. No cellular evidence.
Avshalom Caspi — H-index 219, over 220,000 citations — found a single "p-factor" underlying all mental disorders: "there is something transdiagnostic that all of these disorders share — most of it has to do with disordered thought processes." Different labels, different treatments. One underlying problem.
Read full article →"I think about something scary — I fear. I think about being hurt — I suffer. Imagination, nervous system and body are not separate systems. They are one."
The brain operates across two competing networks. The Task Positive Network handles present-moment experience. The Default Mode Network — consuming up to 80% of total brain activity — generates a continuous simulation from memory and anticipation. This is where suffering lives.
In deep meditation, psychedelic therapy, near-death experiences — the DMN goes quiet. The sense of self disappears, and with it, mental health disorders. Consciousness does not disappear when the self disappears. It expands.
Read full article →"The ego is attempting to eliminate the ego. Desire is being used as the instrument to end desire."
Meditation produces genuine, measurable changes — reproducible high-complexity neural states. The science is real. But practitioners engage because they want something. The practice is initiated by the very mechanism it is trying to dissolve.
The flaw is not the destination. The flaw is asking the ego to be the one who gets you there. What if there was a path that doesn't require the ego's cooperation?
Read full article →"If mindfulness is a measurable brain state — why are we asking people to generate it entirely through willpower and practice?"
For the first time in history, it is possible to measure and non-invasively modulate brain activity with millimetre precision. Humanity cannot iterate and scale what it cannot measure. The moment a phenomenon becomes quantifiable, it becomes engineerable.
The brain state that meditation has been pointing toward for centuries is directly accessible. Not through years of discipline. Not through chemicals. Through a precise, non-invasive approach that works from outside the loop entirely. Consciousness is Unlocked.
Coming to Substack →Three disciplines. One closed loop. Brain state measurement to precision stimulation — in real time.
Adaptive algorithms that read brain state signals in real time — continuously adjusting stimulation parameters to guide toward measurable mindfulness states.
Precise, objective brain state measurement using validated biomarkers — not symptom self-reports. We measure the phenomenon itself, not a proxy.
Non-invasive focused ultrasound targeting the Default Mode Network — the root architecture of rumination and suffering — with millimetre precision.
Our Proof of Concept demonstrates measurably higher mindfulness in 80 seconds — equivalent to the result that requires 60 hours of MBSR programme. The same outcome, radically compressed through precision brain state technology.
Real-time, closed-loop brain state stimulation — built on open science, no side effects.
TIESA's system continuously measures brain states and applies focused ultrasound in a closed feedback loop — automatically guiding toward target states of mindfulness. Adapts in real time. No pharmaceuticals. No side effects. No willpower required.
Partnering with Openwater — founded by Dr. Mary Lou Jepsen — using their Open-LIFU (Low-Intensity Focused Ultrasound) device in AI-guided research targeting the Default Mode Network.
In conversation — consciousness, neuroscience, and the future of mental health.
